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MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells.
Ma X, Zhang X, Luo J, Liang B, Peng J, Chen C, Guo H, Wang Q, Xing X, Deng Q, Huang H, Liao Q, Chen W, Hu Q, Yu D, Xiao Y. Ma X, et al. Toxicol In Vitro. 2020 Aug;66:104830. doi: 10.1016/j.tiv.2020.104830. Epub 2020 Mar 19. Toxicol In Vitro. 2020. PMID: 32198055
Over-expression or down-regulation of miR-486-5p altered MAGI1 and RASSF5 expression and modified erythroid differentiation. Dual-luciferase reporter assay and fluorescence-based RNA electrophoresis mobility assay (FREMSA) further confirmed that miR-486-5p directly bound t …
Over-expression or down-regulation of miR-486-5p altered MAGI1 and RASSF5 expression and modified erythroid differentiation. Dual-luc …
Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.
Carmona G, Göttig S, Orlandi A, Scheele J, Bäuerle T, Jugold M, Kiessling F, Henschler R, Zeiher AM, Dimmeler S, Chavakis E. Carmona G, et al. Blood. 2009 Jan 8;113(2):488-97. doi: 10.1182/blood-2008-02-138438. Epub 2008 Sep 19. Blood. 2009. PMID: 18805968 Free article.
We found that Rap1a and Rap1b are essential for the conformational activation of beta(1)-integrins in endothelial cells. ...Rap1a(-/-)-deficient and Rap1a(+/-) heterozygote mice displayed reduced neovascularization after hind limb ischemia compared with wild- …
We found that Rap1a and Rap1b are essential for the conformational activation of beta(1)-integrins in endothelial cells. ...Rap1a …